Monitoring and controlling the airflow and ventilation both are important to healthcare settings. Airborne disease and infection pose as a potential fatality to already vulnerable individuals. Bacterial transfer can be increased with certain airflow patterns which involve lots of recirculation. This is why ventilation is important in this type of environment so that recirculation can be reduced where possible. Computational fluid dynamics (CFD) simulations were carried out to investigate the airflow and heat transfer taking place inside a Neonatal Intensive Care Unit (NICU). In this study, the NICU was modelled, based on realistic dimensions of a single-patient room in compliance to the appropriate square footage allocated per incubator. ANSYS Fluent was utilized for all simulations to predict the airflows influenced in a forced convection by the air-conditioning and radiant hydronic systems, according to suitable thermophysical characteristics of the climate. The results show sensible flow structures and heat transfer as expected by any indoor climate with this configuration. The flows along the ceiling boundary are uniform until they pass over the light and velocity increases to the same velocity as the initialized flows at an AC inlet. The velocity slows back down to a slightly more stable velocity as it trails down the outlet wall and exits through the vent or recirculates around the room. Eddies occur in a few main zones including over the incubator lid and inside the incubator cavity, particularly in the corners of incubator. Heat transfer between the radiator and air reaches equilibrium where the inlet air was fully circulated, and the room temperature rises to a uniform value of 20 °C. Recirculation is an important area to consider when carrying out airflow predictions in sensitive hospital wards due to bacterial transport. This study conclusively shows the main recirculation zones and where the configuration of the geometry could be altered to decrease the number of these zones.