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ISSN Online: 2377-424X

ISBN Print: 978-1-56700-474-8

ISBN Online: 978-1-56700-473-1

International Heat Transfer Conference 16
August, 10-15, 2018, Beijing, China

A MULTISCALE MODELING METHOD FOR SIMULATION OF FLUID AND HEAT TRANSFER IN BIOLOGICAL TISSUE CONTAINING THE EXACT STRUCTURE OF MICROVASCULAR NETWORK

Get access (open in a dialog) DOI: 10.1615/IHTC16.bma.022959
pages 567-576

Аннотация

The aim of this study is to develop a model of fluid and heat transfer in biological tissue containing the exact structure of microvascular network, and to analyze the influence of structural changes of the network in diabetes on flow and heat transfer. A cubic region representing local skin tissue is selected as the computational domain, which is composed of two sub-domains of intravascular and extravascular parts. To save computing resources, the capillary network is reduced to a 1Dpipeline model and embedded into the extravascular part. According to the concept of immersed boundary method (IBM), fluid and heat fluxes across capillary wall are distributed to surrounding tissue nodes by delta function.
The steady and periodic blood pressure conditions are respectively set at the entrances of capillary network. Under steady blood pressure condition, both the interstitial fluid pressure and tissue temperature around the capillary network are larger than those in other places. Under periodic blood pressure condition, tissue temperature shows the trend of fluctuating with the same frequency, but amplitude attenuation and time delay of the fluctuation waveform occur with the propagation of thermal wave. When the connectivity of capillary network is impaired in diabetes, the capacity of blood redistribution through the capillary network becomes weaker and a part of the vessel branches lose blood flow, which further aggravates amplitude attenuation and time delay of skin temperature fluctuation.