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ISSN Online: 2377-424X

ISBN CD: 1-56700-226-9

ISBN Online: 1-56700-225-0

International Heat Transfer Conference 13
August, 13-18, 2006, Sydney, Australia

OXYGEN TRANSFER IN THE CEREBRAL TISSUE

Get access (open in a dialog) DOI: 10.1615/IHTC13.p30.300
12 pages

Аннотация

Oxygen delivery in the brain tissue is carried out by a convective-diffusion process determined by spatial inhomogeneity of partial pressure of oxygen (pO2). Previous studies identified inhomogeneous distribution of cerebral tissue pO2, which is related to spatial variations in microvascular structure, because large amount of oxygen is supplied from microvascular network. In this study, to evaluate the oxygen transport in cerebral cortex, we focused on regional structure of microvascular network and pO2 distribution in rat somatosensory cortex. To this end, firstly, we quantified three-dimensional microvascular structure by using confocal laser-scanning microscope (CLSM). Secondly, we characterized local tissue pO2 distribution by using an oxygen microelectrode. Finally, we discussed the possible feature of oxygen transfer in the cerebral tissue by numerical simulation of convective-diffusive process based on these experimental data (i.e., pO2 distribution and microvascular structure).