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ISSN Online: 2377-424X

ISBN Print: 978-1-56700-474-8

ISBN Online: 978-1-56700-473-1

International Heat Transfer Conference 16
August, 10-15, 2018, Beijing, China

MICROSCALE THERMAL TRANSPORT: SOME BIOMEDICAL PERSPECTIVES AND BEYOND

Get access (open in a dialog) DOI: 10.1615/IHTC16.kn.000010
pages 229-249

要約

The application areas of microscale thermal transport have dramatically expanded in the past few years, having significant implications in understanding thermophysical phenomena occurring in biological systems and bio-medical devices. In particular, understanding thermal transport in biological tissue has numerous applications in disease diagnosis and therapy, which often demands quantification of the temporal and spatial variations in the tissue temperature. This article aims to introduce researchers to some of the topics on microscale thermal and fluid transport in the broad purview of biomedical applications, as persuaded in the author's research group. At first, laser assisted photo−thermal therapy of biological tissues is discussed, wherein the effect of laser type and laser input configurations on the optimization of therapeutic outcome is outlined. To evaluate the variation in tissue temperature induced by melting of fat and vaporization of water, an enthalpy based bioheat model is illustrated. Further, the potential of plasmonic nanomaterials in improving the tumor specificity during cancer ablation is discussed, along with an experimentally validated predictive model. Subsequently, the working principle and model of magnetic fluid hyperthermia (MFH) is illustrated, wherein the physics of magnetic nanoparticle heating and magnetophoretic transport of nanoparticles through tissues is explained. Next, a new radiometric device for imaging dynamic changes in skin blood perfusion is introduced, wherein the measurement of blood perfusion and its clinical relevance is discussed. Finally, the process of DNA hybridization in microfluidic devices is illustrated, that are widely applicable for determination of DNA sequences. In this regard, a physics based theoretical model of DNA hybridization is discussed considering microscale heat, fluid and ion transport in a microchannel under electrical field and the pressure gradient, bearing far reaching consequences in point of care diagnostic applications employing lab-on-chip micro devices.