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International Heat Transfer Conference 16

ISSN: 2377-424X (online)
ISSN: 2377-4371 (flashdrive)

NUMERICAL ANALYSIS OF EFFECTIVE DAMAGE RADIUS FOR LARGE TUMOR MICROWAVE HYPERTHERMIA

Jing Li
South China University of Technology, 381 Wu Shan Rd. Tianhe District, Guangzhou 510641, China

Huan Yao
South China University of Technology, 381 Wu Shan Rd. Tianhe District, Guangzhou 510641, China

Yan Lei
Southern Medical University Hospital of Traditional Chinese and Western Medicine, 13 Shiliu Gang Rd. Haizhu District, Guangzhou 510315, China

Yanyong Ye
South China University of Technology, 381 Wu Shan Rd. Tianhe District, Guangzhou 510641, China

DOI: 10.1615/IHTC16.cms.023389
pages 1769-1776


KEY WORDS: Numerical simulation and super-computing, Optimal control, Bio and medical applications, Large tumor, Microwave hyperthermia, Effective damaged radius

Abstract

Microwave hyperthermia has achieved significant curative results in large tumor (D>2 cm) therapy because of its large ablation area, short treatment time, and the absence of side effects. However, the effective damage radius due to variations in the treat-time and incident power remains highly uncertain. In this study, a simplified two-dimensional axisymmetric mathematic model was established on the basis of single-probe microwave ablation of large liver tumors of radius 2-4 cm. In addition, the optimum damage condition was obtained as 50 °C/13 s by using the standard of the shortest time required for tissue damage at each monitoring point. Ultimately, the maximum damage radius R, the maximum damage depth H, R/H and the effective damage radius Re, were investigated using damaged tissue integral analysis. The results indicate that H increases faster than R over time, and R/H is primarily influenced by the treatment time (up to 0.39-0.42 at 10 min), but was not significantly impacted by the microwave power. More importantly, for a Re of 2 cm, the treatment conditions at different powers were 50-80 W/4 min and 90-150 W/2 min. The required treatment conditions for a Re of 3 cm were 50 W/10 min, 60-80 W/8 min, 90-130/6 min and 140-150 W/4 min. It was also determined that an Re value of 0.04 m was achieved at the maximum power of 150 W for a treat-time of 10 min.

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